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Theory

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Posttest

References

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Partition coefficient of acetic acid in water and butanol

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(1)How does the polarity of a solute affect its partition coefficient?

a: More polar solute has a higher partition coefficient Explanation

Explanation

b: Depends on the polarity of the solvent Explanation

Explanation

c: Polarity of a solute has no effect on the partition coefficient Explanation

Explanation

d: More polar solute has a lower partition coefficient Explanation

Explanation

(2)High value of partition coefficient signifies?

a: high hydrophobic nature of solute Explanation

Explanation

b: high hydrophilic nature of solute Explanation

Explanation

c: nothing about hydrophilic/hydrophobic nature of solute Explanation

Explanation

d: low hydrophobic nature of solute Explanation

Explanation

(3)Hydrophobic drug with high octanol-water partition coefficient will distribute?

a: more in blood serum (aqueous phase). Explanation

Explanation

b: less in blood serum (aqueous phase). Explanation

Explanation

c: less in lipid bilayer (hydrophobic phase). Explanation

Explanation

d: Negligibly in lipid bilayer (hydrophobic phase). Explanation

Explanation

(4)Partition coefficient of a solute between non polar solvent and water is 0.1. Which statement is true?

a: Solute is more soluble in nonpolar solvent. Explanation

Explanation

b: The solute has equal solubility in both solvents. Explanation

Explanation

c: Solute is more soluble in water. Explanation

Explanation

d: Solute is less dense than water Explanation

Explanation

(5)The partition coefficient of a solute in two solvents can be:

a: Between 0 and 1. Explanation

Explanation

b: Between -1 and 1. Explanation

Explanation

c: Between 0 and infinity. Explanation

Explanation

d: Between -infinity and infinity. Explanation

Explanation

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